Prometeus will develop an innovative brain imaging device (neo-opticap) able to monitor in real-time brain oxygenation, blood flow and metabolism from multiple regions of the head at the cot-side. Neo-optical will be developed by combining two photonics technologies, time-domain near-infrared spectroscopy (TD-nirs) and speckle contrast optical spectroscopy (SCOS), which will be coupled to the newborn’s head via an optimized and ergonomic wearable cap.